Assessing Reproductive Toxicity of Various Environmental Toxicants with a Novel in vitro Spermatogenesis Model
This project utilizes our novel stem cell-based, in vitro model of human spermatogenesis to examine the effects and identify sub-cellular mechanisms of known and unknown/predicted reproductive toxicants on various windows of susceptibility during spermatogenesis. This project is supported by Dr. Easley’s NIEHS K22ES025418 grant.
Effects of Flame Retardant Exposure on Sperm and Future Generations
This project uses an exciting new strategy fusing epidemiological approaches, a hybrid exposomics approach, and a novel in vitro model to determine how exposure to PBB (polybrominated biphenyl) alters the epigenome in male gametes to cause multigenerational consequences.
Using Non-human Primate Pluripotent Stem Cells to Treat Male-factor Infertility
This project is in collaboration with Dr. Anthony Chan at Emory University/Yerkes National Primate Research Center. This project, using non-human primate pluripotent stem cells, tests the concept that functional haploid spermatids can be derived in vitro from pluripotent stem cells and will help determine whether patient-specific pluripotent stem cells can be utilized to treat male factor infertility. This project is supported by a multi-PI NIH grant (lead PI: Dr. Easley) R21OD020182.
Developing a novel in vitro screening model to assess male contraceptives
This Phase I project seeks to build on our current in vitro spermatogenesis model by adding fluorescent reporters to enable high throughput/high content assays to begin identifying potential male contraceptives. This work is supported by Dr. Easley’s Bill and Melinda Gates Grand Challenges Exploration Grant.